3-Azaspiro[5.5]undecane-9-acetic acid, 3-[(1,1-diMethylethoxy)carbonyl]- - Names and Identifiers
3-Azaspiro[5.5]undecane-9-acetic acid, 3-[(1,1-diMethylethoxy)carbonyl]- - Physico-chemical Properties
Molecular Formula | C17H29NO4
|
Molar Mass | 311.42 |
Density | 1.12g/cm3 |
Boling Point | 452.7°C at 760 mmHg |
Flash Point | 227.6°C |
Vapor Presure | 1.86E-09mmHg at 25°C |
Storage Condition | Room Temprature |
Refractive Index | 1.519 |
3-Azaspiro[5.5]undecane-9-acetic acid, 3-[(1,1-diMethylethoxy)carbonyl]- - Introduction
2-([5.5]undecan-3-yl)acetic acid is an organic compound commonly abbreviated as Boc-NASU. The following is a description of the properties, uses, preparation and safety information of the compound:
Nature:
-Appearance: Colorless to slightly yellow solid
-Chemical formula: C18H31NO5
-Molecular weight: 345.5g/mol
-melting point: 77-79 ℃
-Boiling point: 456.2 ℃
-Solubility: Soluble in ethanol, acetone and dimethyl sulfoxide, slightly soluble in water
Use:
-In organic synthesis, Boc-NASU are often used as reagents to protect amino acids in polypeptides or proteins.
-It can form Boc-amino acid ester by reacting with amino acid, thereby protecting the active amino group.
- Boc-NASU can also be used to synthesize other nitrogen-containing organic compounds.
Preparation Method:
-The preparation of Boc-NASU is usually carried out by reacting aminospiranone with tri-tert-butyl phosphonic acid oxide (TBOP) under the catalysis of a base to obtain the Boc-NASU precursor compound.
-Then, the precursor compound is reacted with acetic anhydride to obtain the final product Boc-NASU.
Safety Information:
- Boc-NASU may be harmful to health, so safe operating procedures should be followed when using it.
-It is an irritating compound that may cause irritation to the eyes, skin and respiratory tract.
-Use with appropriate personal protective equipment, such as lab gloves and goggles.
-Avoid inhalation, ingestion, or contact with skin. If contact occurs, flush the affected area with plenty of water and seek medical attention.
-storage should avoid high temperature and open fire, it is recommended in a cool, dry place sealed preservation.
Last Update:2024-04-10 22:29:15